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Ion channel linked receptors : ウィキペディア英語版 | Ion channel linked receptors
Ion channel linked receptors are cell membrane bound receptors. They act through synaptic signaling on electrically excitable cells and convert chemical signals (ligand) to electrical ones.〔http://www.scq.ubc.ca/cell-surface-receptors-a-biological-conduit-for-information-transfer/〕 It is essential in neuronal activities. Ion-channel-linked receptors are also called ''ligand-gated channels''. These membrane-spanning proteins undergo a conformational change when a ligand binds to them so that a "tunnel" is opened through the membrane to allow the passage of a specific molecule. These ligands can be neurotransmitters or peptide hormones, and the molecules that pass through are often ions, such as sodium (Na+) or potassium (K+), which can alter the charge across the membrane. The ion channels, or pores, are opened only for a short time, after which the ligand dissociates from the receptor and the receptor is available once again for a new ligand to bind. == Mechanism ==
Ion-channel linked receptors mostly located on synaptic structures (diag1 on the right). They form a functional synapse, which is the basic structure of neural activities. When presynaptic neuron is excited, it would release neurotransmitter from a vesicle. The neurotransmitter will bind to receptors located on the postsynaptic neuron, and open the ion channels, which led to a flow of ion (could be Na2+, K+, Ca2+, or Cl-, could be flow in or out, depends on the type of neurotransmitter and the receptor). Then the potential of the postsynaptic neuron change (elevate if the neurotransmitter is excitatory; decline if inhibitory). The postsynaptic neuron excites when its overall potential reach the action potential, that is, the threshold for its presynaptic structure to release neurotransmitter to the next related neuron.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Ion channel linked receptors」の詳細全文を読む
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